The Arterial Dynamics Platform: 7 Microfluidic Cores

Arterial Dynamics applies advanced, label-free fluid mechanics to eliminate shear-induced cellular trauma in therapeutic apheresis, biomanufacturing, and clinical diagnostics.

Our core architecture utilizes Dean forces and inertial lift in phase-locked microfluidic channels to selectively process fragile cells—without high G-forces, mechanical filters, or harsh chemical tags.

Core Applications & Pipeline

Cores 1–4: Clinical & Therapeutic Applications

  • Core 1: Sickle Cell Disease & Acute Exchange (Flagship Module)
    Targeted depletion of rigid, damaged irreversibly sickled erythrocytes (ISCs) during vaso-occlusive crisis (VOC) to restore microvascular perfusion while reducing overall transfusion burden.
  • Core 2: High-Yield Mobile Blood Processing
    Scalable, field-deployable cell preservation and washing circuits designed for rapid trauma care and point-of-need operations.
  • Core 3: Gentle Leukapheresis
    Non-destructive isolation of fragile immune cells (PBMCs, T-cells) for cell therapies without activating shear-sensitive cell surface markers.
  • Core 4: Extracorporeal Microaggregate Depletion
    Selective removal of microthrombi and cellular debris during prolonged extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass.

Cores 5–7: Research, Biomanufacturing & Diagnostics

  • Core 5: Point-of-Care Bio-Manufacturing
    Compact, continuous-flow cell enrichment module integrated with automated bioreactor loops.
  • Core 6: High-Throughput Rare Cell Separation
    Microfluidic enrichment of low-abundance target cells from whole blood for diagnostic research.
  • Core 7: Diagnostic Circulating Tumor Cell (CTC) Enrichment
    Gentle isolation of viable CTCs and circulating biomarkers for downstream genomic and transcriptomic analysis.

Key Technical Advantages

  • Label-Free Operation: No antibodies, magnetic beads, or chemical reagents required.
  • Hemolysis Prevention: Eliminates high-shear mechanical filters and centrifugal forces to preserve cell membrane integrity.
  • Scalable Cassettes: Single-use, closed-loop fluidic channels engineered for modular parallel processing.